Brian Locke

#Anaphylaxis and Angioedema

Angioedema

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Dermal, SQ, mucosal swelling - non pitting. vasodilation and increased vascular permeability.

24-72 hour course

  • idiopathic
  • associated with allergic and non-allergic reactions due to antigens (e.g. venom, drugs, foods, pathogens, animals, latex(
  • C1-INH deficiency: inherited or acquired

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Drugs

https://www.sciencedirect.com/science/article/pii/S1323893015302550?via%3Dihub

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~50 % associated with urticartia

  • ACEi: never associated with urticaria

  • NSAID: non allergic alt

  • Antibiotics (particularly beta-lactam)

Management

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Anaphylaxis

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alt# Angioedema and Anaphylaxis