Brian Locke

Estimating GFR All commonly used equations for estimating GFR in the ICU are unacceptably precise and biased toward overesti...

Angioedema alt Dermal, SQ, mucosal swelling - non pitting. vasodilation and increased vascular permeability. 24-...

Do not renally adjust first dose of antibiotics (pharmacokinetics of first dose: concentration in blood is a result of vo...

In Salt Lake City (correction for atmospheric pressure - based on intermountain group work): severe P/F < 85 moderate 85 < P...

Contraindications and complications Vascular injury? Indication arterial BP readings (note: central = axillary, fem are ...

Aspiration Per Barb - conceptualize as amount aspirated vs clearance rate (as apposed to binary). Also, lung microbi...

GINA EPR3 ATS/ERS management of severe asthma NEJM 2017 Severe and Difficult to treat asthma Definitions Atopy: predispositio...

In the ICU: Pathogenesis: 1. Arrythmogenic substrate and 2. trigger (e.g. electrolytes, PANS/SANS activation). Without the...

Patient Scenario: Blurb 1 Respiratory Failure: The pulmonary system has two primary roles, each of which ca...

Learning goals: rebuild an understanding of electrolyte balance from the clinical application to the scientific / physiolo...

Immersion: body surrounded by water; exposed to external hydrostatic pressure. increases inspiratory effort (static load),...

Presentation: think of nonsmoker with COPD, hemoptysis NOTE: MAC (some debate if it's a chicken or egg came first) Unknown why ...

Bronchoalveolar lavage for pneumonia in immunocompromised patients https://pubmed.ncbi.nlm.nih.gov/31541573/ In hematopoietic s...

Contraindications In elective placement: ?INR 2.5, Plt 40 -> consider products. (Consider other reasons for platel...

indications: Pneumothorax if (ventilated, tension, persistent/recurrent, secondary large + 50y/o) Penetrating chest trauma ...

Coagulopathy Are patients with cirrhosis who have an increased INR at decreased risk of clot? No Patients with c...

https://www.nejm.org/doi/full/10.1056/nejmoa1101388 Pathology Membranous bronchioles develop mural smooth muscle...

Source: DOI: 10.1183/09031936.00048514 3 components: central medullary rhythm/pattern generator and integrator (b...

Inhalers Triple Inhalers No increase in exacerbation risk for patients stable on triple inhalers (who do not have asthma or eo...

Ref: DOI: 10.1002/cphy.c110048 Indications: - Mechanisms of residual DOE: https://www.atsjournals.org/doi/full/10.1513/AnnalsATS.202004-3...